2086274-31-7
2086274-31-7 structure
- Name: Axl-IN-21
- Chemical Name: Axl-IN-21
- CAS Number: 2086274-31-7
- Molecular Formula: C22H26N6O5S2
- Molecular Weight: 518.607
- Create Date: 2020-01-11 19:28:40
- Modify Date: 2024-04-03 09:09:53
-
Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.
| Name | Axl-IN-21 |
|---|
| Description | Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer. |
|---|---|
| References | References 1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer) |
| Molecular Formula | C22H26N6O5S2 |
|---|---|
| Molecular Weight | 518.607 |