Axl-IN-21

Modify Date: 2024-04-03 09:09:53

Axl-IN-21 structure	Common Name	Axl-IN-21
	CAS Number	2086274-31-7	Molecular Weight	518.607
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₆N₆O₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Axl-IN-21

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.

Name	Axl-IN-21

Description	Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.
References	References 1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer)

Molecular Formula	C₂₂H₂₆N₆O₅S₂
Molecular Weight	518.607

DC Chemicals Limited
China
Product Name: Axl-IN-21
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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