Axl-IN-21 structure
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Common Name | Axl-IN-21 | ||
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CAS Number | 2086274-31-7 | Molecular Weight | 518.607 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C22H26N6O5S2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Axl-IN-21Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer. |
Name | Axl-IN-21 |
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Description | Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer. |
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References | References 1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer) |
Molecular Formula | C22H26N6O5S2 |
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Molecular Weight | 518.607 |