Axl-IN-21

Modify Date: 2024-04-03 09:09:53

Axl-IN-21 Structure
Axl-IN-21 structure
Common Name Axl-IN-21
CAS Number 2086274-31-7 Molecular Weight 518.607
Density N/A Boiling Point N/A
Molecular Formula C22H26N6O5S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Axl-IN-21


Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.

 Names

Name Axl-IN-21

 Axl-IN-21 Biological Activity

Description Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.
References References 1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer)

 Chemical & Physical Properties

Molecular Formula C22H26N6O5S2
Molecular Weight 518.607
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