1263303-95-2
1263303-95-2 structure
- Name: DHODH-IN-11
- Chemical Name: DHODH-IN-11
- CAS Number: 1263303-95-2
- Molecular Formula: C15H11N3O2
- Molecular Weight: 265.27
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-04-07 15:09:08
- Modify Date: 2024-01-10 13:24:09
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DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].
| Name | DHODH-IN-11 |
|---|
| Description | DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1]. |
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| Related Catalog | |
| Target |
pKa: 5.03 (DHODH)[1] |
| In Vitro | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1]. |
| References |
| Molecular Formula | C15H11N3O2 |
|---|---|
| Molecular Weight | 265.27 |
| Hazard Codes | Xi |
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