1473403-87-0

1473403-87-0 structure

Name: MC-SN38
Chemical Name: MC-SN38
CAS Number: 1473403-87-0
Molecular Formula: C₃₂H₃₁N₃O₈
Molecular Weight: 585.60
Create Date: 2020-08-11 13:19:42
Modify Date: 2024-01-12 20:02:48
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].

Name	MC-SN38

Description	MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Molecular Formula	C₃₂H₃₁N₃O₈
Molecular Weight	585.60

Hazard Codes	Xi