MC-SN38

Modify Date: 2025-08-25 17:06:37

MC-SN38 structure	Common Name	MC-SN38
	CAS Number	1473403-87-0	Molecular Weight	585.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₁N₃O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MC-SN38

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].

Name	MC-SN38

Description	MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Description

Related Catalog

Research Areas >> Cancer

References

[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.

[2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Molecular Formula	C₃₂H₃₁N₃O₈
Molecular Weight	585.60

Hazard Codes	Xi

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MC-SN38
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Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.