2292116-14-2

2292116-14-2 structure

Name: Desmorpholinyl Quizartinib-PEG2-COOH
Chemical Name: Desmorpholinyl Quizartinib-PEG2-COOH
CAS Number: 2292116-14-2
Molecular Formula: C₃₀H₃₃N₅O₇S
Molecular Weight: 607.68
Create Date: 2021-01-06 20:32:28
Modify Date: 2024-01-02 16:15:56
Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].

Name	Desmorpholinyl Quizartinib-PEG2-COOH

Description	Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].
Related Catalog	Research Areas >> Cancer
References	[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

Molecular Formula	C₃₀H₃₃N₅O₇S
Molecular Weight	607.68

Hazard Codes	Xi