Desmorpholinyl Quizartinib-PEG2-COOH

Modify Date: 2024-01-02 16:15:56

Desmorpholinyl Quizartinib-PEG2-COOH Structure
Desmorpholinyl Quizartinib-PEG2-COOH structure
Common Name Desmorpholinyl Quizartinib-PEG2-COOH
CAS Number 2292116-14-2 Molecular Weight 607.68
Density N/A Boiling Point N/A
Molecular Formula C30H33N5O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Desmorpholinyl Quizartinib-PEG2-COOH


Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].

 Names

Name Desmorpholinyl Quizartinib-PEG2-COOH

 Desmorpholinyl Quizartinib-PEG2-COOH Biological Activity

Description Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].
Related Catalog
References

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

 Chemical & Physical Properties

Molecular Formula C30H33N5O7S
Molecular Weight 607.68

 Safety Information

Hazard Codes Xi
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