353512-04-6
353512-04-6 structure
- Name: JAK2-IN-6
- Chemical Name: (4-Amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone
- CAS Number: 353512-04-6
- Molecular Formula: C14H10ClN3OS2
- Molecular Weight: 335.832
- Create Date: 2021-01-22 09:31:26
- Modify Date: 2025-09-19 09:40:26
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JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells.
| Name | (4-Amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone |
|---|---|
| Synonyms |
(4-Amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone
Methanone, [4-amino-2-(phenylamino)-5-thiazolyl](5-chloro-2-thienyl)- |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.6±60.0 °C at 760 mmHg |
| Molecular Formula | C14H10ClN3OS2 |
| Molecular Weight | 335.832 |
| Flash Point | 304.3±32.9 °C |
| Exact Mass | 334.995392 |
| LogP | 3.06 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.748 |