Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Buclizine dihydrochloride
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Buclizine dihydrochloride
Price: ￥178.0/5g ￥648.0/25g
Purity: 99.0%
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DC Chemicals Limited
China
Product Name: AH 2526
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: AH 2526
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Buclizine hydrochloride
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Purity: 98.0%
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129-74-8

129-74-8 structure

129-74-8 structure

Name: Buclizine dihydrochloride
Chemical Name: anileridine dihydrochloride
CAS Number: 129-74-8
Molecular Formula: C₂₈H₃₅Cl₃N₂
Molecular Weight: 505.950
Catalog: Biochemical Inhibitor Neuronal Signaling Histamine Receptor Inhibitor
Create Date: 2018-07-16 18:22:13
Modify Date: 2024-01-08 10:31:13
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].

Name	anileridine dihydrochloride
Synonyms	1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)piperazine dihydrochloride Posdel 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine dihydrochloride 1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine dihydrochloride MFCD00242700 Buclina 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride 1-(p-tert-Butylbenzyl)-4-(p-chloro-a-phenylbenzyl)piperazine Dihydrochloride 1-[(4-Chlorophenyl)(phenyl)methyl]-4-[4-(2-methyl-2-propanyl)benzyl]piperazine dihydrochloride Postafen BUCLIZINE, DIHYDROCHLORIDE buclizine hydrochloride Piperazine, 1- (p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride buclizine dihydrochloride Longifene Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2) 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine dihydrochloride Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride

Description	Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Buclizine (0-100 μM, 72 h) inhibited cancer cell growth by binding to TCTP and induction of cell differentiation[3]. Cell Proliferation Assay[3]. Cell Line: MCF-7 cells[3]. Concentration: 0-100 μM. Incubation Time: 72 h. Result: The IC50 was 19.18 ± 5.32 μM.
In Vivo	Buclizine dihydrochloride (≥40 mg/kg) exhibits teratogenic effect[1]. Buclizine dihydrochloride exhibits the t1/2 of ~10 h via oral administration[2]. Animal Model: Eighty-seven mature female rats weighing 240±20 grams[1]. Dosage: 30-200 mg/kg. Administration: From days 10 to 15. Result: Exhibits teratogenic effect dose-dependently when ≥40 mg/kg.
References	[1]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [2]. Nawab Sher, et al. Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and buclizine in pharmaceutical formulations, human serum and pharmacokinetics application. Analytical methods • March 2014. [3]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget . 2016 Mar 29;7(13):16818-39.

Boiling Point	520.1ºC at 760 mmHg
Melting Point	230-240ºC
Molecular Formula	C₂₈H₃₅Cl₃N₂
Molecular Weight	505.950
Flash Point	268.3ºC
Exact Mass	504.186584
PSA	6.48000
LogP	8.02450
Vapour Pressure	6.44E-11mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL0280000

CHEMICAL NAME :: Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl )-, dihydrochloride

CAS REGISTRY NUMBER :: 129-74-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H33-Cl-N2.2Cl-H

MOLECULAR WEIGHT :: 506.00

WISWESSER LINE NOTATION :: T6N DNTJ AYR&R DG& D1R DX1&1&1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 360 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 95,109,1966

Hazard Codes	Xi

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