1263184-04-8

1263184-04-8 structure

Name: MK-571-d6 sodium salt
Chemical Name: MK-571-d6 sodium salt
CAS Number: 1263184-04-8
Molecular Formula: C₂₆H₂₁D₆ClN₂NaO₃S₂
Molecular Weight: 543.11
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2021-10-19 17:43:14
Modify Date: 2024-01-10 09:54:43
MK-571-d6 (L-660711-d6) sodium salt is the deuterium labeled MK-571 sodium salt. MK-571 sodium salt is a selective, orally active leukotriene D4 receptor antagonist, with Kis of 0.22 and 2.1 nM in guinea pig and human lung membranes[1][2].

Name	MK-571-d6 sodium salt

Description	MK-571-d6 (L-660711-d6) sodium salt is the deuterium labeled MK-571 sodium salt. MK-571 sodium salt is a selective, orally active leukotriene D4 receptor antagonist, with Kis of 0.22 and 2.1 nM in guinea pig and human lung membranes[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. [3]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97.

Molecular Formula	C₂₆H₂₁D₆ClN₂NaO₃S₂
Molecular Weight	543.11