DC Chemicals Limited
China
Product Name: Nur77 modulator 2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2055829-03-1

2055829-03-1 structure

2055829-03-1 structure

Name: Nur77 modulator 2
Chemical Name: Nur77 modulator 2
CAS Number: 2055829-03-1
Molecular Formula: C₂₆H₂₅NO₅
Molecular Weight: 431.48
Create Date: 2022-05-13 10:44:31
Modify Date: 2024-01-23 10:18:01
Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].

Name	Nur77 modulator 2

Description	Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	Kd: 0.35 μM (Nur77)[1]
In Vitro	Nur77 modulator 2 (Compound B7) significantly decreases the production of cytokines in vitro, such as NO, IL-6, IL-1β, and TNF-α, at concentrations of 1.25 μM, 2.5 μM, and 5 μM. Nur77 modulator 2 inhibits the lipopolysaccharides (LPS)-induced inflammation via the blockade of NF-κB activation in a Nur77-dependent manner[1].
In Vivo	Nur77 modulator 2 (Compound B7; 5-10 mg/kg; p.o; for 1 week) shows in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI)[1].
References	[1]. Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645.

Molecular Formula	C₂₆H₂₅NO₅
Molecular Weight	431.48