2055829-03-1
2055829-03-1 structure
- Name: Nur77 modulator 2
- Chemical Name: Nur77 modulator 2
- CAS Number: 2055829-03-1
- Molecular Formula: C26H25NO5
- Molecular Weight: 431.48
- Create Date: 2022-05-13 10:44:31
- Modify Date: 2025-08-26 00:03:18
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Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].
| Name | Nur77 modulator 2 |
|---|
| Description | Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1]. |
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| Related Catalog | |
| Target |
Kd: 0.35 μM (Nur77)[1] |
| In Vitro | Nur77 modulator 2 (Compound B7) significantly decreases the production of cytokines in vitro, such as NO, IL-6, IL-1β, and TNF-α, at concentrations of 1.25 μM, 2.5 μM, and 5 μM. Nur77 modulator 2 inhibits the lipopolysaccharides (LPS)-induced inflammation via the blockade of NF-κB activation in a Nur77-dependent manner[1]. |
| In Vivo | Nur77 modulator 2 (Compound B7; 5-10 mg/kg; p.o; for 1 week) shows in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI)[1]. |
| References |
| Molecular Formula | C26H25NO5 |
|---|---|
| Molecular Weight | 431.48 |