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2173556-92-6

2173556-92-6 structure
2173556-92-6 structure
  • Name: RIPK1-IN-12
  • Chemical Name: RIPK1-IN-12
  • CAS Number: 2173556-92-6
  • Molecular Formula: C24H26N4O3S
  • Molecular Weight: 450.55
  • Create Date: 2022-07-02 17:40:15
  • Modify Date: 2024-01-10 09:03:15
  • RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].

Name RIPK1-IN-12
Description RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].
Related Catalog
Target

RIPK1[1]

In Vitro RIPK1-IN-12 (Compound 58; 24 hours) demonstrates potent anti-necroptotic activity (EC50=1.6 nM in HT-29 cells and EC50= 2.9 nM in L929 cells)[1].
References

[1]. Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.

Molecular Formula C24H26N4O3S
Molecular Weight 450.55