2408317-70-2

2408317-70-2 structure
2408317-70-2 structure
  • Name: FAK-IN-5
  • Chemical Name: FAK-IN-5
  • CAS Number: 2408317-70-2
  • Molecular Formula: C29H29ClF3N3O4
  • Molecular Weight: 576.01
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2022-07-11 17:39:11
  • Modify Date: 2024-01-17 23:47:56
  • FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy[1].

Name FAK-IN-5
Description FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy[1].
Related Catalog
In Vitro FAK-IN-5 (Compound 8l) (0-50 µM, 72 h) shows antiproliferative activity against cancer cells[1]. FAK-IN-5 (Compound 8l) causes cell detachment[1]. FAK-IN-5 (Compound 8l) (0-25 µM, 24 h) induces autophagy and apoptosis in HCT-116 cells[1]. Cell Proliferation Assay[1] Cell Line: K562, CEM, G361, MCF-7 and HCT-116 Concentration: 0-50 µM Incubation Time: 72 h Result: Showed antiproliferative activity with IC50 values of 6.3, 7.9, 6.3, 5.5 and 5.3 µM against K562, CEM, G361, MCF-7 and HCT-116 cells, respectively. Western Blot Analysis[1] Cell Line: HCT-116 Concentration: 1.25, 2.5, 5, 7, 10, 11, 17 and 25 µM Incubation Time: 1, 3, 5, 7 and 24 h Result: Caused the dephosphorylation of FAK, p130Cas and paxillin in a dose-dependent manner. The dephosphorylation of FAK at Y397 was observed at a much earlier time point. Detected the fragments of activated caspase-7 as well as the dose-dependent cleavage of poly (ADP-ribose) polymerase (PARP).
References

[1]. Jorda R, et al. Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells. Eur J Med Chem. 2020 Feb 15;188:112036.

Molecular Formula C29H29ClF3N3O4
Molecular Weight 576.01
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