104260-73-3

104260-73-3 structure

Name: Collagen-IN-1
Chemical Name: Collagen-IN-1
CAS Number: 104260-73-3
Molecular Formula: C₁₄H₁₄O₃
Molecular Weight: 230.26
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-07-01 20:45:38
Modify Date: 2024-01-02 16:49:48
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1].

Name	Collagen-IN-1

Description	Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Diego Méndez, et al. Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Eur J Med Chem. 2020 Apr 15;192:112187.

Molecular Formula	C₁₄H₁₄O₃
Molecular Weight	230.26