2414633-40-0

2414633-40-0 structure

Name: hCAIX-IN-8
Chemical Name: hCAIX-IN-8
CAS Number: 2414633-40-0
Molecular Formula: C₁₉H₁₆N₄O₆
Molecular Weight: 396.35
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-07-01 21:05:22
Modify Date: 2024-04-06 20:35:39
hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].

Name	hCAIX-IN-8

Description	hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]
In Vitro	hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively[1]. hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].
References	[1]. Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.

Molecular Formula	C₁₉H₁₆N₄O₆
Molecular Weight	396.35