2476764-11-9

2476764-11-9 structure

Name: MPO-IN-5
Chemical Name: MPO-IN-5
CAS Number: 2476764-11-9
Molecular Formula: C₂₄H₂₄N₆O₂
Molecular Weight: 428.49
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2022-08-18 14:29:51
Modify Date: 2024-01-27 13:42:58
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].

Name	MPO-IN-5

Description	MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
References	[1]. Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.

Molecular Formula	C₂₄H₂₄N₆O₂
Molecular Weight	428.49