Name | Androgen receptor antagonist 5 |
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Description | Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1]. |
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Related Catalog | |
Target |
IC50: 6.17 μM (AR)[1] |
In Vitro | Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1]. |
References |
Molecular Formula | C21H15F4N5O3S |
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Molecular Weight | 493.43 |