Androgen receptor antagonist 5
Modify Date: 2024-01-29 11:12:53
Androgen receptor antagonist 5 structure
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Common Name | Androgen receptor antagonist 5 | ||
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| CAS Number | 2586195-28-8 | Molecular Weight | 493.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H15F4N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Androgen receptor antagonist 5Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1]. |
| Name | Androgen receptor antagonist 5 |
|---|
| Description | Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 6.17 μM (AR)[1] |
| In Vitro | Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1]. |
| References |
| Molecular Formula | C21H15F4N5O3S |
|---|---|
| Molecular Weight | 493.43 |