2444363-11-3

2444363-11-3 structure

Name: EGFR/HER2/TS-IN-1
Chemical Name: EGFR/HER2/TS-IN-1
CAS Number: 2444363-11-3
Molecular Formula: C₂₄H₁₅N₅O₄S₂
Molecular Weight: 501.54
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-12 16:28:15
Modify Date: 2024-01-21 08:38:15
EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].

Name	EGFR/HER2/TS-IN-1

Description	EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Thymidylate Synthase Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.203 μM (IC50) HER2:0.088 μM (IC50) Thymidylate synthase:0.168 μM (IC50)
In Vitro	EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC50 of 0.693 μM against MCF7 cells[1]. EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells[1]. Cell Cycle Analysis[1] Cell Line: MCF7 Concentration: 10 μg Incubation Time: 24 h Result: Arrested cell cycle at G2/M phase. Apoptosis Analysis[1] Cell Line: MCF7 Concentration: 10 μg Incubation Time: 24 h Result: Induced cell apoptosis.
References	[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.

Molecular Formula	C₂₄H₁₅N₅O₄S₂
Molecular Weight	501.54