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1676107-08-6

1676107-08-6 structure

1676107-08-6 structure

Name: BACE2-IN-1
Chemical Name: BACE2-IN-1
CAS Number: 1676107-08-6
Molecular Formula: C₃₆H₃₈F₃N₃O₃
Molecular Weight: 617.70
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2022-11-02 19:39:52
Modify Date: 2024-04-11 16:54:08
BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].

Name	BACE2-IN-1

Description	BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Metabolic Disease
Target	BACE2:1.6 nM (Ki) BACE1:815.1 nM (Ki)
In Vitro	BACE2-IN-1 (compound 3l) inhibits BACE2 with an Ki value of 1.6 nM, 500 fold over BACE1 (Ki = 815.1 nM)[1].
References	[1]. Ghosh AK, et al. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. 2019 Mar 5. 14(5):545-560.

Molecular Formula	C₃₆H₃₈F₃N₃O₃
Molecular Weight	617.70

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