2567724-20-1
2567724-20-1 structure
- Name: Nampt-IN-10 TFA
- Chemical Name: Nampt-IN-10 TFA
- CAS Number: 2567724-20-1
- Molecular Formula: C29H29F4N5O4
- Molecular Weight:
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Nampt
- Create Date: 2022-10-07 12:07:17
- Modify Date: 2024-01-06 12:57:37
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Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1].
| Name | Nampt-IN-10 TFA |
|---|
| Description | Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1]. |
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| Related Catalog | |
| Target |
IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)[1] |
| In Vitro | Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines[1]. Cell Cytotoxicity Assay[1] Cell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines Concentration: 0-1 μM Incubation Time: 72 hours Result: Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC50 values of 5, 19, 2, 0.4 and 1 nM, respectively. |
| References |
| Molecular Formula | C29H29F4N5O4 |
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