309247-48-1

309247-48-1 structure

Name: Protein Kinase C (19-35) Peptide
Chemical Name: Protein Kinase C (19-35) Peptide
CAS Number: 309247-48-1
Molecular Formula: C₈₉H₁₅₃N₃₃O₂₂
Molecular Weight: 2037.40
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2023-01-23 07:38:08
Modify Date: 2024-04-03 12:41:58
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive[1][2].

Name	Protein Kinase C (19-35) Peptide

Description	Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
In Vitro	Amino acids equivalent to residues 19-36 and 19-29 of PKC-β can bound to phospholipid vesicles[2]. Atypical zeta protein kinase C in the signaling pathway leading to chemoattractant-triggered actin assembly, integrin-dependent adhesion of blood leukocytes to vascular endothelium[3]. Synthetic myristoylated peptides with Protein Kinase C (19-35) Peptide, the endogenous zeta protein kinase C pseudosubstrate region, block agonist-induced adhesion to fibrinogen, chemotaxis and F-actin accumulation[3].
References	[1]. Steiner J, et al. The effect of acute ethanol (EtOH) exposure on protein kinase C (PKC) activity in anterior pituitary. Alcohol. 1997 May-Jun;14(3):209-11. [2]. Mosior M, et al. Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J. 1991 Jul;60(1):149-59. [3]. Laudanna C, et al. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem. 1998 Nov 13;273(46):30306-15.

Molecular Formula	C₈₉H₁₅₃N₃₃O₂₂
Molecular Weight	2037.40