219769-23-0

219769-23-0 structure

Name: SB-284851-BT
Chemical Name: SB-284851-BT
CAS Number: 219769-23-0
Molecular Formula: C₂₆H₂₆FN₅O
Molecular Weight: 443.52
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2023-04-18 15:58:51
Modify Date: 2025-09-08 19:34:30
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET)[1][2].

Name	SB-284851-BT

Description	SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	p38α:0.47 nM (Kd) BRD4-BD1:1.7 μM (IC50) BRDT (1):18 μM (IC50) BRD4(1):3.7 μM (IC50)
References	[1]. Divakaran A, et al. Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J Med Chem. 2018 Oct 25;61(20):9316-9334. [2]. Jin W, et al. Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions. Drug Discov Today. 2022 Jan;27(1):246-256.

Molecular Formula	C₂₆H₂₆FN₅O
Molecular Weight	443.52