SB-284851-BT

Modify Date: 2024-04-08 18:25:59

SB-284851-BT structure	Common Name	SB-284851-BT
	CAS Number	219769-23-0	Molecular Weight	443.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆FN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SB-284851-BT

SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET)[1][2].

Name	SB-284851-BT

Description	SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	p38α:0.47 nM (Kd) BRD4-BD1:1.7 μM (IC50) BRDT (1):18 μM (IC50) BRD4(1):3.7 μM (IC50)
References	[1]. Divakaran A, et al. Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J Med Chem. 2018 Oct 25;61(20):9316-9334. [2]. Jin W, et al. Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions. Drug Discov Today. 2022 Jan;27(1):246-256.

Molecular Formula	C₂₆H₂₆FN₅O
Molecular Weight	443.52

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SB-284851-BT

Use of SB-284851-BT

Names

SB-284851-BT Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.