2170274-53-8

2170274-53-8 structure

Name: SPC-180002
Chemical Name: SPC-180002
CAS Number: 2170274-53-8
Molecular Formula: C₁₈H₂₃NO₄
Molecular Weight: 317.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2023-11-24 16:31:43
Modify Date: 2024-01-09 19:57:16
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].

Name	SPC-180002

Description	SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT1:1.13 ± 0.3 μM (IC50) SIRT3:5.41 ± 4.8 μM (IC50)
References	[1]. Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.

Molecular Formula	C₁₈H₂₃NO₄
Molecular Weight	317.38