SPC-180002
Modify Date: 2024-01-09 19:57:16
SPC-180002 structure
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Common Name | SPC-180002 | ||
|---|---|---|---|---|
| CAS Number | 2170274-53-8 | Molecular Weight | 317.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H23NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SPC-180002SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1]. |
| Name | SPC-180002 |
|---|
| Description | SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1]. |
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| Related Catalog | |
| Target |
SIRT1:1.13 ± 0.3 μM (IC50) SIRT3:5.41 ± 4.8 μM (IC50) |
| References |
| Molecular Formula | C18H23NO4 |
|---|---|
| Molecular Weight | 317.38 |