Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hydrocortisone 21-hemisuccinate
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Purity: 99.0%
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2203-97-6

2203-97-6 structure

Name: Hydrocortisone hemisuccinate
Chemical Name: Hydrocortisone 21-hemisuccinate
CAS Number: 2203-97-6
Molecular Formula: C₂₅H₃₄O₈
Molecular Weight: 462.533
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-04-04 08:00:00
Modify Date: 2026-07-10 14:13:57
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].

Name	Hydrocortisone 21-hemisuccinate
Synonyms	HYDROCORTISONEHEMISUCCINATE(ANHYDROUS) Cortisol 21-(4-oxo-4-hydroxybutanoate) MFCD00046256 saxizon 21-(3-Cboxy-1-oxopropoxy)-11β,17-dihydroxypregn-4-ene-3,20-dione 20-dione 21-hemisuccinate Butanedioic acid, mono(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) ester hydrocortisone hemisuccinate ester C12888 2-oxoethoxy) Hydrocortisone hydrogen succinate 11b,17a,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE Butanedioic acid, mono[(11α)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester hydrocortisone21-hemisuccinatefreeacid Pregn-4-ene-3,20-dione,21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxy-, (11b) 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid Hydrocortisone 21-he Hydrocortisone acetate half Kohaku Hydrocortisone 21-hemisuccinate //BP HYDROCORTISONE 21-HEMISUCCINATE Hydrocortisone hydrogen succinate CRS 4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE 21-HEMISUCCINATE 4-{[(11α)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid Cortisol, 21-(hydrogen succinate) (8CI) 4-[(11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid hydrocortisone21-succinate EINECS 218-612-3 21-Trihydroxy-4-pregnene-3 HYDROCORTISONE HEMISUCCINATE 4-(2-((8S,9S,10R,11S,13S,14S,17R) Hydrocortisone Succinate RS Hydrocortisone hemisuccinate anhydrous，Hydrocortisone 21-hemisuccinate Hydrocortizone Succinate HYDROCORTISONE HYDROGEN SUCCINATE HYDROCORTISONE SUCCINATE 17-dihydroxy-20-dion(11-beta)-preg-4-ene-21-(3-cboxy-1-oxopropoxy)-11 Cortisol, hydrogen succinate (7CI) cortisol,hydrogensuccinate cortisolsuccinate 21-(3-Cboxy-1-oxopropoxy)-11β,17α-dihydroxypregn-4-ene-3,20-dione 11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate HYDROXYCORTISONE SUCCINATE Pregn-4-ene-3,20-dione, 21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β) 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione21-(hydrogensuccinate) CORTISOL 21-HEMISUCCINATE hydrocortisone-21-O-hemisuccinate 4-(2-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid RMA-279 cortisol,21-(hydrogensuccinate) 4-PREGNEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE Hydrocortisone Hemisuccinate Monomer hydrocortisone 21-(hydrogen succinate) (11-beta)-21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxypreg-4-ene-3,20-dione 11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl) CORTISOL HEMISUCCINATE Hydrocortisone hemisuccinate, 10 mM in DMSO 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE hydrocortisone 21-hemisuccinatefree acid

Description	Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	IL-6:6.7 μM (IC50) IL-3:21.4 μM (IC50)
In Vitro	Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].
In Vivo	Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2] Dosage: 30 mg/kg Administration: P.o. twice daily for 5 days Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.
References	[1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73.

Density	1.3±0.1 g/cm3
Boiling Point	685.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₄O₈
Molecular Weight	462.533
Flash Point	231.1±25.0 °C
Exact Mass	462.225372
PSA	138.20000
LogP	2.13
Vapour Pressure	0.0±4.8 mmHg at 25°C
Index of Refraction	1.587
Storage condition	−20°C
Water Solubility	Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5010147

CHEMICAL NAME :: Preg-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11-beta)-

CAS REGISTRY NUMBER :: 2203-97-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H34-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/10W-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4704 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16945 (estimated) No. of Female Employees: 15681 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5010147

108-30-5

50-23-7

~98%

2203-97-6

Literature: Wang, Chao; Zhao, Ming; Qiu, Xuecai; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4403 - 4421

Precursor 2
108-30-5 50-23-7
DownStream 1
50-23-7

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