Hydrocortisone hemisuccinate

Modify Date: 2024-01-04 12:47:40

Hydrocortisone hemisuccinate structure	Common Name	Hydrocortisone hemisuccinate
	CAS Number	2203-97-6	Molecular Weight	462.533
	Density	1.3±0.1 g/cm3	Boiling Point	685.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₃₄O₈	Melting Point	N/A
	MSDS	USA	Flash Point	231.1±25.0 °C

Use of Hydrocortisone hemisuccinate

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].

Name	Hydrocortisone 21-hemisuccinate
Synonym	More Synonyms

Description	Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	IL-6:6.7 μM (IC50) IL-3:21.4 μM (IC50)
In Vitro	Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].
In Vivo	Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2] Dosage: 30 mg/kg Administration: P.o. twice daily for 5 days Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.
References	[1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73.

Density	1.3±0.1 g/cm3
Boiling Point	685.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₄O₈
Molecular Weight	462.533
Flash Point	231.1±25.0 °C
Exact Mass	462.225372
PSA	138.20000
LogP	2.13
Vapour Pressure	0.0±4.8 mmHg at 25°C
Index of Refraction	1.587
Storage condition	−20°C
Water Solubility	Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5010147

CHEMICAL NAME :: Preg-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11-beta)-

CAS REGISTRY NUMBER :: 2203-97-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H34-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/10W-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4704 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16945 (estimated) No. of Female Employees: 15681 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5010147

Succinic anhydride

CAS#:108-30-5

Hydrocortisone

CAS#:50-23-7

~98%

Hydrocortisone ...

CAS#:2203-97-6

Literature: Wang, Chao; Zhao, Ming; Qiu, Xuecai; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4403 - 4421

Precursor 2
CAS#:108-30-5 Succinic anhydride CAS#:50-23-7 Hydrocortisone
DownStream 1
CAS#:50-23-7 Hydrocortisone

Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.

Am. J. Vet. Res. 73(1) , 68-75, (2012)

To compare daily endogenous cortisol production rate and the pharmacokinetics of an i.v. bolus of hydrocortisone between neonatal foals and adult horses.10 healthy full-term 2- to 4-day-old foals and ...

The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration.

Crit. Care Resusc. 15(1) , 63-6, (2013)

Bolus dose concentrations of hydrocortisone (50mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of...

Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.

Steroids 75(12) , 853-8, (2010)

Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expre...

Hydrocortisone 21-he

MFCD00046256

saxizon

cortisol,hydrogensuccinate

cortisolsuccinate

Butanedioic acid, mono(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) ester

hydrocortisone hemisuccinate ester

4-{[(11α)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid

CORTISOL HEMISUCCINATE

Hydrocortisone hydrogen succinate

4-[(11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid

Hydrocortisone hemisuccinate

EINECS 218-612-3

CORTISOL 21-HEMISUCCINATE

hydrocortisone-21-O-hemisuccinate

Hydrocortizone Succinate

Butanedioic acid, mono[(11α)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester

hydrocortisone21-hemisuccinate*freeacid

HYDROCORTISONE SUCCINATE

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hydrocortisone hemisuccinate
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hydrocortisone hemisuccinate
Price: ￥1428.0/1g
Purity: 95.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Hydrocortisone hemisuccinate anhydrous
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hydrocortisone 21-hemisuccinate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥500/10 mM * 1 mL in DMSO

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Hydrocortisone hemisuccinate

Use of Hydrocortisone hemisuccinate

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