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  • Product Name: Aloin
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

8015-61-0

8015-61-0 structure
8015-61-0 structure
  • Name: Aloin
  • Chemical Name: (1S)-1,5-Anhydro-1-[(9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9 ,10-dihydro-9-anthracenyl]-D-glucitol
  • CAS Number: 8015-61-0
  • Molecular Formula: C21H22O9
  • Molecular Weight: 418.394
  • Catalog: Natural product Anthraquinone
  • Create Date: 2018-04-23 08:00:00
  • Modify Date: 2024-01-06 10:23:39
  • Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs)[1][2].

Name (1S)-1,5-Anhydro-1-[(9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9 ,10-dihydro-9-anthracenyl]-D-glucitol
Synonyms (1S)-1,5-Anhydro-1-[(9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol
isobarbaloin
(10R)-10-β-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone
9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (R)-
10-(1',5'-Anhydroglucosyl)-aloe-emodin-9-anthrone
(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-9(10H)-anthracenone
D-Glucitol, 1,5-anhydro-1-C-[(9R)-9,10-dihydro-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9-anthracenyl]-, (1S)-
(1S)-1,5-Anhydro-1-[(9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydro-9-anthracenyl]-D-glucitol
Description Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs)[1][2].
Related Catalog
Target

MMPs[2]

References

[1]. Jiang M, et al. Evaluation of the Antioxidative, Antibacterial, and Anti-Inflammatory Effects of the Aloe Fermentation Supernatant Containing Lactobacillus plantarum HM218749.1. Mediators Inflamm. 2016;2016:2945650.

[2]. Barrantes E, et al. Inhibition of collagenase and metalloproteinases by aloins and aloe gel. Life Sci. 2003 Jan 3;72(7):843-50.

Density 1.6±0.1 g/cm3
Boiling Point 752.6±60.0 °C at 760 mmHg
Molecular Formula C21H22O9
Molecular Weight 418.394
Flash Point 268.0±26.4 °C
Exact Mass 418.126373
PSA 167.91000
LogP 1.86
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.741
Water Solubility pyridine: 50 mg/mL, clear, dark red

Section 1. Chemical Product and Company Identification
Aloin
Common Name/
Trade Name
Aloin

Section 4. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Not available.
Serious Ingestion

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards in
Risks of explosion of the product in presence of static discharge: Not available.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated
Special Remarks on
temperatures
Fire Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Special Remarks on
explosion hazard.
Explosion Hazards

Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
Small Spill
water on the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
Large Spill
the contaminated surface and allow to evacuate through the sanitary system.
Aloin

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
breathe dust.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage

Section 8. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering Controls
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
of a Large Spill
handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Solid. (Powdered solid.)Not available.
Physical state andO dor
appearance
Bitter.
Taste
418.39 g/mole
Molecular Weight
Yellowish-brown. Yellow.
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
148°C (298.4°F)
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
Not available.
Dispersion Properties
Not available.
Solubility

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat.
Incompatibility with various Not available.
substances
Non-corrosive in presence of glass.
Corrosivity
Aloin
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

Section 11. Toxicological Information
Inhalation. Ingestion.
Routes of Entry
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Other Toxic Effects on
Humans
Not available.
Special Remarks on
Toxicity to Animals
Not available.
Special Remarks on
Chronic Effects on Humans
Acute Potential Health Effects:
Special Remarks on other
Skin: It can cause skin irritation.
Toxic Effects on Humans
Eyes: It can cause eye irritation.
Inhalation: It may cause respiratory tract irritation.
Ingeston: It has laxative properties and increases the perstaltic contractions in the colon. It also prevents the colon
from re-absorbing water from the gastrointestinal tract, which leads to softer stools. Ingestion of large amounts may
cause abdominal pain, diarrhea, an electrolyte imbalance.

Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation

Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control
Waste Disposal
regulations.

Section 14. Transport Information
Not a DOT controlled material (United States).
DO T Cl assi fi cati on
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
Aloin
DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Aloin
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
This product is not classified according Not applicable.
DSCL (EEC)
to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Aloin
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26;S36
WGK Germany 3
HS Code 2938909090
HS Code 2938909090