307002-73-9

307002-73-9 structure

Name: WAY 170523
Chemical Name: WAY 170523,N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
CAS Number: 307002-73-9
Molecular Formula: C₃₃H₃₁N₃O₇S
Molecular Weight: 613.68
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2016-12-16 01:05:22
Modify Date: 2024-01-24 15:58:36
WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].

Name	WAY 170523,N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide

Description	WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP13:17 nM (IC50) MMP-1:10 μM (IC50) MMP-9:945 nM (IC50)
In Vitro	WAY-170523 has an IC50 of 17 nM for MMP-13 and shows > 5800-, 56-, and > 500-fold selectivity against MMP-I, MMP-9, and TACE, respectively.
References	[1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654. [2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.

RIDADR	NONH for all modes of transport