BioBioPha
China
Product Name: (+)-Corynoline
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (+)-Corynoline
Price: ￥1920.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (+)-corynoline
Price: $1100.0/250mg $2100.0/1g $600.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: CORYNOLINE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

18797-79-0

18797-79-0 structure

18797-79-0 structure

Name: (+)-Corynoline
Chemical Name: Corynoline
CAS Number: 18797-79-0
Molecular Formula: C₂₁H₂₁NO₅
Molecular Weight: 367.395
Catalog: Biochemical Plant extracts
Create Date: 2018-09-16 06:37:27
Modify Date: 2024-01-05 20:15:33
Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Name	Corynoline
Synonyms	(11S,13R,14R)-corynoline 13-Methylchelidonine 13-methyl-chelidonine Corynoline [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)-

Description	Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9. [2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Density	1.4±0.1 g/cm3
Boiling Point	504.2±50.0 °C at 760 mmHg
Melting Point	217-218ºC
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.395
Flash Point	258.7±30.1 °C
Exact Mass	367.141968
PSA	60.39000
LogP	3.23
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.659

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330
Precautionary Statements	P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	UN 1544PSN1 6.1 / PGII

Precursor 0
DownStream 1
18797-80-3