(+)-Corynoline

Modify Date: 2024-01-05 20:15:33

(+)-Corynoline structure	Common Name	(+)-Corynoline
	CAS Number	18797-79-0	Molecular Weight	367.395
	Density	1.4±0.1 g/cm3	Boiling Point	504.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₁NO₅	Melting Point	217-218ºC
	MSDS	Chinese USA	Flash Point	258.7±30.1 °C
	Symbol	GHS06	Signal Word	Danger

Use of (+)-Corynoline

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Name	Corynoline
Synonym	More Synonyms

Description	Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9. [2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Description

Related Catalog

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

References

[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.

[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Density	1.4±0.1 g/cm3
Boiling Point	504.2±50.0 °C at 760 mmHg
Melting Point	217-218ºC
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.395
Flash Point	258.7±30.1 °C
Exact Mass	367.141968
PSA	60.39000
LogP	3.23
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.659

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330
Precautionary Statements	P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	UN 1544PSN1 6.1 / PGII