737-52-0

737-52-0 structure

Name: Oxypeucedanin
Chemical Name: oxypeucedanin
CAS Number: 737-52-0
Molecular Formula: C₁₆H₁₄O₅
Molecular Weight: 286.279
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-09-29 09:48:31
Modify Date: 2024-01-02 15:10:17
Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

Name	oxypeucedanin
Synonyms	4-(3,3-Dimethyl-oxiranylmethoxy)-furo[3,2-g]chromen-7-one 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3,3-dimethyloxiranyl)methoxy)- 5-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one 4-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one 7H-Furo[3,2-g][1]benzopyran-7-one, 5-[(3,3-dimethyloxiranyl)methoxy]- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3,3-dimethyloxiranyl)methoxy]- Oxypencedanin 5-[(3,3-Dimethyloxiran-2-yl)methoxy]-7H-furo[3,2-g]chromen-7-one oxypeucadanin

Description	Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: HKv1.5 current; apoptosis[1]
References	[1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60. [2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

Hazard Codes	Xi

482-45-1

~86%

737-52-0

Literature: Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610

486-60-2

737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

484-20-8

737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

870-63-3

737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610