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Product Name: Kynuramine Dihydrobromide
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304-47-2

304-47-2 structure

304-47-2 structure

Name: Kynuramine Dihydrobromide
Chemical Name: Kynuramine dihydrobromide
CAS Number: 304-47-2
Molecular Formula: C₉H₁₄Br₂N₂O
Molecular Weight: 326.02800
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-06-20 18:55:29
Modify Date: 2025-08-25 09:03:49
Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

Name	Kynuramine dihydrobromide
Synonyms	3-(2-Aminophenyl)-3-oxopropanamine 3-amino-1-(2-aminophenyl)propan-1-one,hydrobromide

Description	Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Metabolic Disease
In Vitro	Kynuramine (dihydrobromide) 在体外抑制突触前和突触后 α-肾上腺素受体[2]。 Kynuramine 已被证明是狗脑动脉血清素受体的部分激动剂[2]。 Kynuramine (20 μg/mL) 经常导致回肠轻微收缩，但未能改变胆碱能刺激的抽搐反应[2]。
In Vivo	Kynuramine (dihydrobromide) (0.064、0.32、1.6 或 8 μg；脑室内；单剂量) 促进雌激素激发的去卵巢大鼠前凸行为[3]。 Kynuramine (1.25、2.5 和 5.0 mg/kg；静脉注射；单剂量) 可增加大鼠的心率和血压[4]。 Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular injection; single does. Result: Produced facilitation of lordosis behavior. Animal Model: Male rats (about 200g)[4]. Dosage: 1.25-5.0 mg/kg. Administration: Intravenous injection; single does. Result: Promoted heart rate and blood pressure.
References	[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.

Boiling Point	367.3ºC at 760mmHg
Molecular Formula	C₉H₁₄Br₂N₂O
Molecular Weight	326.02800
Flash Point	175.9ºC
Exact Mass	323.94700
PSA	69.11000
LogP	3.99800
Storage condition	20°C

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RIDADR	NONH for all modes of transport
WGK Germany	3

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