306387-90-6

306387-90-6 structure

Name: Cyclopamine-KAAD
Chemical Name: N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
CAS Number: 306387-90-6
Molecular Formula: C₄₄H₆₃N₃O₄
Molecular Weight: 697.99
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2018-11-28 17:17:02
Modify Date: 2024-01-09 21:59:06
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

Name	N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
Synonyms	Cyclopamine-KAAD Shh Signaling Antagonist II 3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine KAAD-Cyclopamine

Description	KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
In Vitro	KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].
References	[1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30. [2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.

Hazard Codes	Xi