Cyclopamine-KAAD

Modify Date: 2024-01-09 21:59:06

Cyclopamine-KAAD Structure
Cyclopamine-KAAD structure
Common Name Cyclopamine-KAAD
CAS Number 306387-90-6 Molecular Weight 697.99
Density 1.15g/cm3 Boiling Point 875.6ºC at 760 mmHg
Molecular Formula C44H63N3O4 Melting Point N/A
MSDS N/A Flash Point 483.3ºC

 Use of Cyclopamine-KAAD


KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

 Names

Name N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
Synonym More Synonyms

 Cyclopamine-KAAD Biological Activity

Description KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].
Related Catalog
In Vitro KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].
References

[1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30.

[2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.

 Chemical & Physical Properties

Density 1.15g/cm3
Boiling Point 875.6ºC at 760 mmHg
Molecular Formula C44H63N3O4
Molecular Weight 697.99
Flash Point 483.3ºC
Exact Mass 697.48200
PSA 101.73000
LogP 8.40240
Index of Refraction 1.588

 Safety Information

Hazard Codes Xi

 Synonyms

Cyclopamine-KAAD
Shh Signaling Antagonist II
3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine
KAAD-Cyclopamine
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