21104-28-9

21104-28-9 structure

Name: Mahanimbine
Chemical Name: 3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazole
CAS Number: 21104-28-9
Molecular Formula: C₂₃H₂₅NO
Molecular Weight: 331.45100
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2016-12-07 00:20:19
Modify Date: 2024-01-08 14:26:19
Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].

Name	3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazole
Synonyms	Mahanimbine dl-mahanimbine (+-)-Mahanimbin Pyrano(3,2-a)carbazole,3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-pentenyl)-,(+) Dihydromahanimbin (+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole,Mahanimbin 3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3,11-dihydropyrano[3,2-a]carbazole 3,5-dimethyl-3-(4-methyl-pent-3-enyl)-3,11-dihydro-pyrano[3,2-a]carbazole (+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-pentenyl)pyrano[3,2-a]carbazole Rel-(+)-Mahanimbine dehydroxy-mahanine

Description	Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vivo	Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1]. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1]. Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1]. Animal Model: Swiss albino mice (7-8 weeks old, both sex)[1] Dosage: HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); Administration: Oral suspension; daily for 12 weeks Result: Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain.
References	[1]. Jagtap S, et al. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations. Biofactors. 2017 Mar;43(2):220-231.

Hazard Statements	H413
Risk Phrases	53
RIDADR	NONH for all modes of transport

24224-30-4