1434-54-4
1434-54-4 structure
- Name: Pregnenolone 16α-carbonitrile
- Chemical Name: pregnenolone 16α-carbonitrile
- CAS Number: 1434-54-4
- Molecular Formula: C22H31NO2
- Molecular Weight: 341.487
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2018-12-26 10:29:21
- Modify Date: 2024-01-13 16:43:08
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Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P4503A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults[1][2][3].
| Name | pregnenolone 16α-carbonitrile |
|---|---|
| Synonyms |
(3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
MFCD00079212 (3β,16α)-3-Hydroxy-20-oxopregn-5-ene-16-carbonitrile 16 α-Carbonitrile, Pregnenolone 3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile pregnenolone 16alpha-carbonitrile pregnenolone carbonitrile Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)- Pregnenolone 16α-carbonitrile Pregnenolone-16alpha-carbonitrile 5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile |
| Description | Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P4503A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Pregnenolone 16α-carbonitrile (20 μM; 9 days) directly inhibits rat hepatic stellate cell (HSCs) transdifferentiation to a profibrogenic phenotype, although the cells did not express the PXR (in contrast with hepatocytes)[4]. |
| In Vivo | Pregnenolone 16α-carbonitrile (40 mg/kg/day; i.p.; for two days) induces the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice[1]. Pregnenolone 16α-carbonitrile (100 mg/kg; ip; single dose) induces the expression of CYP3A mRNA in adult female Sprague-Dawley rats weighing 150-200 g[2]. Pregnenolone 16α-carbonitrile (35 mg/kg; gavage; once daily for three days) increase in Pgp expression in male Sprague-Dawley rats, aged approximately 100 days and weighing 250-400 g[3]. Animal Model: WT and Pxr-/- mice[1] Dosage: 40 mg/kg Administration: IP; per day for two days Result: Induced the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice. Had little effect on the expression of Cyp3a11 in Pxr-/- mice |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 508.5±50.0 °C at 760 mmHg |
| Molecular Formula | C22H31NO2 |
| Molecular Weight | 341.487 |
| Flash Point | 261.3±30.1 °C |
| Exact Mass | 341.235474 |
| PSA | 61.09000 |
| LogP | 3.22 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.558 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | TU4536500 |
|
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1434-54-4 |
| Literature: Tetrahedron, , vol. 7, p. 130,136 Journal of the Chemical Society, , p. 3748 Tetrahedron, , vol. 3, p. 37,40 |
