Tetraethylene glycol monotosylate
Modify Date: 2024-01-10 06:25:18
Tetraethylene glycol monotosylate structure
|
Common Name | Tetraethylene glycol monotosylate | ||
|---|---|---|---|---|
| CAS Number | 77544-60-6 | Molecular Weight | 348.41200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H24O7S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
Use of Tetraethylene glycol monotosylateTetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
| Name | 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Molecular Formula | C15H24O7S |
|---|---|
| Molecular Weight | 348.41200 |
| Exact Mass | 348.12400 |
| PSA | 110.67000 |
| LogP | 1.21000 |
| Symbol |
GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H314 |
| Precautionary Statements | P280-P301 + P310-P305 + P351 + P338-P310 |
| RIDADR | UN 2927 8(6.1) / PGII |
| HS Code | 2909499000 |
| Flash Point(F) | >230 °F |
| Flash Point(C) | >110 °C |
|
~98%
Tetraethylene g... CAS#:77544-60-6 |
| Literature: Park, Ki Duk; Liu, Rihe; Kohn, Harold Chemistry and Biology, 2009 , vol. 16, # 7 p. 763 - 772 |
|
~85%
Tetraethylene g... CAS#:77544-60-6 |
| Literature: Organic Letters, , vol. 4, # 14 p. 2329 - 2332 |
|
~81%
Tetraethylene g... CAS#:77544-60-6 |
| Literature: Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077 |
| Precursor 3 | |
|---|---|
| DownStream 10 | |
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CAS#:437655-95-3| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
| toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester |
| tetraglycol-Ts |
| Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,1-(4-Methylbenzenesulfonate) |
| [2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate |
| Ts-tetraglycol |
| tetraethyleneglycol monotosylate |