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86073-88-3

86073-88-3 structure
86073-88-3 structure
  • Name: LHRH (salmon) acetate salt
  • Chemical Name: Luteinizing hormone releasing hormone salmon
  • CAS Number: 86073-88-3
  • Molecular Formula: C60H73N15O13
  • Molecular Weight: 1212.31000
  • Catalog: Peptides
  • Create Date: 2018-12-31 14:37:38
  • Modify Date: 2025-08-23 11:43:10
  • Luteinizing Hormone Releasing Hormone (LH-RH), salmon is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

Name Luteinizing hormone releasing hormone salmon
Synonyms pyr-his-trp-ser-tyr-gly-trp-leu-pro-gly-nh2
Pyr-HWSYGWLPG-NH2
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
Description Luteinizing Hormone Releasing Hormone (LH-RH), salmon is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.
Related Catalog
In Vitro Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions.LHRH acts as an antimitogenic factor through the activation of the Gi-cAMP intracellular signaling pathway. LHRH might act as an inhibitory factor on both cell proliferation and metastatic behavior in melanoma cells[1]. The hypothalamic decapeptide luteinizing hormone-releasing hormone (LHRH) plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn promote gonadal functions and regulate sex steroid secretion. The effects of LHRH are mediated by high-affinity G protein-coupled LHRH-receptor (LHRH-R) on pituitary gonadotropes. The responses to LHRH vary under different conditions and critically depend on the regimens of administration and doses delivered to gonadotrope cells[2].
References

[1]. Moretti RM, et al. Inhibitory activity of luteinizing hormone-releasing hormone on tumor growth and progression. Endocr Relat Cancer. 2003 Jun;10(2):161-7.

[2]. Horvath JE, et al. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15048-53.

Molecular Formula C60H73N15O13
Molecular Weight 1212.31000
Exact Mass 1211.55000
PSA 426.02000
LogP 2.37720
Storage condition -20°C
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R60
Safety Phrases 53-22-36/37/39-45
RIDADR NONH for all modes of transport
WGK Germany 3.0
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