4192-90-9

4192-90-9 structure

Name: Trilobatin
Chemical Name: 1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
CAS Number: 4192-90-9
Molecular Formula: C₂₁H₂₄O₁₀
Molecular Weight: 436.409
Catalog: Natural product Chalcone
Create Date: 2018-08-30 09:00:22
Modify Date: 2025-08-21 17:38:41
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

Name	1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
Synonyms	UNII:23298I791N 1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- 3,5-Dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl β-D-glucopyranoside p-Phloridzin phloretin-4-D-glucoside T6OTJ BOR CQ EQ DV2R DQ&& CQ DQ EQ F1Q &&β-D-Gluco Form p-Phlorizin 1-Propanone, 1-(4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)- Trilobatin 1-(4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone

Description	Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT
Target	HIV-1 SGLT1/2
In Vitro	Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].
References	[1]. Gao J, et al. Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci. 2018 Jul 30;11:267. [2]. Yin S, et al. Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett. 2018 Jul;592(13):2361-2377.

1133352-99-4

~49%

4192-90-9

Literature: Gupte, Amol; Buolamwini, John K. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 917 - 921

18916-17-1

4192-90-9

Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936

10236-47-2

4192-90-9

Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936

50376-43-7

4192-90-9

Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936