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60-82-2

60-82-2 structure
60-82-2 structure
  • Name: Phloretin
  • Chemical Name: phloretin
  • CAS Number: 60-82-2
  • Molecular Formula: C15H14O5
  • Molecular Weight: 274.269
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Thiopyrimidine
  • Create Date: 2018-03-18 08:00:00
  • Modify Date: 2026-07-02 08:48:01
  • Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].
Name phloretin
Synonyms Phloretin -2
Dihydronaringenin
Dihydroningenin|||NSC 407292|||RJC
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
Phloretin 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
oretin
Liposomal Phloretin,Water Soluble Phloretin,NanoActive Phloretin, Phloretin NanoEmulsion
MFCD00002288
4,2',4',6'-TETRAHYDROXYDIHYDROCHALCONE
Phloretin, (HPLC)
β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone
Phloretin,β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
b-(p-Hydroxyphenyl)phloropropiophenone
UNII-S5J5OE47MK
Phloretin, 10 mM in DMSO
2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone
2',4,4',6'-Tetrahydroxy-α,β-dihydro-trans-chalcone
Phloretin>
BETA-(4-HYDROXYPHENYL)-2,4,6-TRIHYDROXY-PROPIOPHENONE
β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 2μ,4μ,6μ-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
EINECS 200-488-7
PHLORETIN(RG)
2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-PROPIOPHENONE
Phloretin - - Calbiochem
Nanoactive Phloretin
factory Phloretin -2
Phloretin(Dihydroningenin)
2',4',6',4-tetrahydroxydihydrochalcone
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
PHLORETIN
phloretol
4,2',4',6'-tetrahydroxydihydrochalcone
Dihydroningenin
2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-1-PROPIOPHENONE
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)
METHYL-4-4-(4-HYDROXYDIPHENYL METHYL)-PIPERIDINE-1-OXOBUTYL-2,2-DIMETHYLPHENYL ACETIC ACID.FEXOFENADINE INTERMEDIATE
2,4,6-TRIHYDROXY-BETA-(4-HYDROXYPHENYL)PROPIOPHENONE
Floretin
Phloretin Nano-Liposome
3-[4-HYDROXYPHENYL]-1-[2,4,6-TRIHYDROXYPHENYL]-1-PROPANONE
2',4',6'-TRIHYDROXY-3-P-HYDROXYPHENYLPROPIOPHENONE
Phloretin -2 Natural Plant Extracts
Phloretin (6CI)
Phloretol
Water-Soluble Phloretin
Nano Liposomal Phloretin
Phloretin-RM
QR CQ EQ BV2R DQ
PHLORETIN (NATURAL)
Icitin Impurity 7
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6
β-(p-Hydroxyphenyl)phloropropiophenone
Phloridin
2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
Asebogenol
trihydroxyphenyl)
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
2',4',6',4-TETRAHYDROXYDIHYDROCHALCONE
Phloretin Synonyms 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Description Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].
Related Catalog
References

[1]. CHAN SS, LOTSPEICH WD. Comparative effects of phlorizin and phloretin on glucose transport in the cat kidney. Am J Physiol. 1962 Dec;203:975-9.

[2]. Huang WC, Chang WT, Wu SJ, Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures. Mol Nutr Food Res. 2013 Jun 17.

[3]. Luo H, Wang YJ, Chen J, Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.

[4]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.

[5]. Najafian M, Jahromi MZ, Nowroznejhad MJ, Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Mol Biol Rep. 2012 May;39(5):5299-306.
Density 1.4±0.1 g/cm3
Boiling Point 534.4±29.0 °C at 760 mmHg
Melting Point ~260 °C
Molecular Formula C15H14O5
Molecular Weight 274.269
Flash Point 291.1±20.8 °C
Exact Mass 274.084137
PSA 97.99000
LogP 3.50
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.685
Storage condition 2-8°C
Water Solubility soluble
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2942000000
HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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