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Product Name: FTI-2153
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344900-92-1

344900-92-1 structure

344900-92-1 structure

Name: FTI-2153
Chemical Name: fti-2153
CAS Number: 344900-92-1
Molecular Formula: C₂₅H₃₀N₄O₃S
Molecular Weight: 466.59600
Catalog: Research Areas Cancer
Create Date: 2016-02-17 17:15:25
Modify Date: 2025-08-25 19:44:41
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].

Name	fti-2153

Description	FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.

Molecular Formula	C₂₅H₃₀N₄O₃S
Molecular Weight	466.59600
Exact Mass	466.20400
PSA	121.41000
LogP	4.48120

Hazard Codes	Xi

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