10141-51-2
10141-51-2 structure
- Name: 4-(3-Methylbutoxy)aniline hydrochloride (1:1)
- Chemical Name: 4-(3-methylbutoxy)aniline,hydrochloride
- CAS Number: 10141-51-2
- Molecular Formula: C11H18ClNO
- Molecular Weight: 215.72
- Catalog: Signaling Pathways Apoptosis Ferroptosis
- Create Date: 2017-07-29 19:13:06
- Modify Date: 2024-01-24 09:28:42
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CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].
| Name | 4-(3-methylbutoxy)aniline,hydrochloride |
|---|---|
| Synonyms |
4-(3-Methylbutoxy)aniline hydrochloride (1:1)
Benzenamine, 4-(3-methylbutoxy)-, hydrochloride (1:1) 4-Isopentyloxy-anilin,Hydrochlorid 4-isopentyloxy-aniline,hydrochloride p-Isopentoxyaniline |
| Description | CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.015 μM (delta6D in ABMC-7 cells), 0.56 μM (delta6D in Liver microsomes), 0.67 μM (delta5D in ABMC-7 cells), 3.4 μM (delta5D in ABMC-7 cells)[1] |
| In Vitro | CP-24879 (hydrochloride) (0-10 μM, 4 days) inhibits Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and decrease in LTC4 production[1]. CP-24879 (hydrochloride) (0-10 μM, 16 h) shows the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes[2]. CP-24879 (hydrochloride) (0-10 μM, 16 h) blocks LPS-induced expression of inflammatory cytokines in a concentration-dependent manner[2]. CP-24879 (hydrochloride) (0-2 μM, 4 h) inhibits desaturase activity and ameliorates ferroptosis[3]. Cell Viability Assay Cell Line: Mouse mastocytoma ABMC-7 cells[1] Concentration: 0, 100 nM, 300 nM, 1 μM, 3 μM, and 10 μM Incubation Time: 4 days Result: Inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and decrease in LTC4 (Leukotriene C4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity. |
| In Vivo | CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1]. CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1]. Animal Model: Chow-fed and EFAD Balb/C mice (N = 5/group) [1] Dosage: 3 mg/kg Administration: IP, three times a day, for 6 or 4 days Result: Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively). Animal Model: Swiss-Webster mice (male, 25 g) [1] Dosage: 33 mg/kg Administration: IV in the tail vein, once (Pharmacokinetic Analysis) Result: Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min). |
| References |
| Boiling Point | 322.1ºC at 760 mmHg |
|---|---|
| Melting Point | 154-159ºC |
| Molecular Formula | C11H18ClNO |
| Molecular Weight | 215.72 |
| Flash Point | 148.6ºC |
| Exact Mass | 215.107697 |
| PSA | 35.25000 |
| LogP | 4.07690 |
| Vapour Pressure | 0.000208mmHg at 25°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |