10141-51-2

10141-51-2 structure

Name: 4-(3-Methylbutoxy)aniline hydrochloride (1:1)
Chemical Name: 4-(3-methylbutoxy)aniline,hydrochloride
CAS Number: 10141-51-2
Molecular Formula: C₁₁H₁₈ClNO
Molecular Weight: 215.72
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2017-07-29 19:13:06
Modify Date: 2024-01-24 09:28:42
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].

Name	4-(3-methylbutoxy)aniline,hydrochloride
Synonyms	4-(3-Methylbutoxy)aniline hydrochloride (1:1) Benzenamine, 4-(3-methylbutoxy)-, hydrochloride (1:1) 4-Isopentyloxy-anilin,Hydrochlorid 4-isopentyloxy-aniline,hydrochloride p-Isopentoxyaniline

Description	CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.015 μM (delta6D in ABMC-7 cells), 0.56 μM (delta6D in Liver microsomes), 0.67 μM (delta5D in ABMC-7 cells), 3.4 μM (delta5D in ABMC-7 cells)[1]
In Vitro	CP-24879 (hydrochloride) (0-10 μM, 4 days) inhibits Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and decrease in LTC4 production[1]. CP-24879 (hydrochloride) (0-10 μM, 16 h) shows the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes[2]. CP-24879 (hydrochloride) (0-10 μM, 16 h) blocks LPS-induced expression of inflammatory cytokines in a concentration-dependent manner[2]. CP-24879 (hydrochloride) (0-2 μM, 4 h) inhibits desaturase activity and ameliorates ferroptosis[3]. Cell Viability Assay Cell Line: Mouse mastocytoma ABMC-7 cells[1] Concentration: 0, 100 nM, 300 nM, 1 μM, 3 μM, and 10 μM Incubation Time: 4 days Result: Inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and decrease in LTC4 (Leukotriene C4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity.
In Vivo	CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1]. CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1]. Animal Model: Chow-fed and EFAD Balb/C mice (N = 5/group) [1] Dosage: 3 mg/kg Administration: IP, three times a day, for 6 or 4 days Result: Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively). Animal Model: Swiss-Webster mice (male, 25 g) [1] Dosage: 33 mg/kg Administration: IV in the tail vein, once (Pharmacokinetic Analysis) Result: Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min).
References	[1]. Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. [2]. [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. [3]. [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442.

Boiling Point	322.1ºC at 760 mmHg
Melting Point	154-159ºC
Molecular Formula	C₁₁H₁₈ClNO
Molecular Weight	215.72
Flash Point	148.6ºC
Exact Mass	215.107697
PSA	35.25000
LogP	4.07690
Vapour Pressure	0.000208mmHg at 25°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

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