6525-53-7

6525-53-7 structure

Name: Dimethyl Glutamate
Chemical Name: (S)-Dimethyl 2-aminopentanedioate
CAS Number: 6525-53-7
Molecular Formula: C₇H₁₃NO₄
Molecular Weight: 175.18200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-12 12:10:14
Modify Date: 2025-08-25 18:00:54
Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].

Name	(S)-Dimethyl 2-aminopentanedioate
Synonyms	dimethyl L-glutamate L-glutamic acid a,g-dimethyl ester glutamic acid dimethyl ester L-glutamic acid dimethyl ester Dimethyl Glutamate Einecs 229-414-1

Description	Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Anti-infection >> Bacterial
Target	KATP channel[4]
References	[1]. J Cancelas, et al. Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. Int J Mol Med. 2001 Nov;8(5):531-2. [2]. Sener A, et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology-Endocrinology and Metabolism, 1994, 267(4): E573-E584. [3]. I S Owens, et al. Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester. J Protozool. 1969 May;16(2):211-5. [4]. Hidenori Katsuta, et al. Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 beta cells. Biochem Biophys Res Commun. 2003 Nov 21;311(3):660-4.

Hazard Codes	Xi