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6610-56-6 29028-10-2
1660118-44-4

6610-56-6

6610-56-6 structure
6610-56-6 structure
  • Name: glochidiol
  • Chemical Name: (1β,3α)-Lup-20(29)-ene-1,3-diol
  • CAS Number: 6610-56-6
  • Molecular Formula: C30H50O2
  • Molecular Weight: 442.72
  • Catalog: Natural product Moss
  • Create Date: 2017-10-29 05:33:56
  • Modify Date: 2024-01-16 17:02:43
  • Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].
Name (1β,3α)-Lup-20(29)-ene-1,3-diol
Synonyms glochidiol
(1β,3α)-Lup-20(29)-ene-1,3-diol
Lup-20(29)-ene-1,3-diol, (1β,3α)-
Description Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].
Related Catalog
Target

IC50: 2.76 μΜ (tubulin polymerization)[1]

In Vitro Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性[1]。 Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用[1]。 Cell Proliferation Assay[1] Cell Line: NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 Concentration: 1, 2, 4 and 8 μM Incubation Time: 48 h Result: Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively.
In Vivo Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长[1]。 Animal Model: BALB/c nude mice bearing HCC-44 xenografts[1] Dosage: 60 mg/kg/day Administration: Intragastric administration for a period of 21 days Result: Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
References

[1]. Chen H, et al. Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin. Invest New Drugs. 2021 Apr;39(2):578-586.  

Density 1.0±0.1 g/cm3
Boiling Point 518.1±50.0 °C at 760 mmHg
Molecular Formula C30H50O2
Molecular Weight 442.72
Flash Point 208.7±24.7 °C
Exact Mass 442.381073
PSA 40.46000
LogP 9.35
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.527
Hazard Codes Xi
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