- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sodium oxamate
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Sodium oxamate
- Price: ￥518.0/25g ￥148.0/5g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Sodium Oxamate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Oxamic acid sodium salt
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
565-73-1
565-73-1 structure
- Name: Sodium oxamate
- Chemical Name: oxamic acid sodium salt
- CAS Number: 565-73-1
- Molecular Formula: C2H2NNaO3
- Molecular Weight: 111.032
- Catalog: Biochemical Common amino acids and protein drugs
- Create Date: 2018-05-17 08:00:00
- Modify Date: 2024-01-02 10:31:30
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Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].
| Name | oxamic acid sodium salt |
|---|---|
| Synonyms |
Sodium oxamate
MFCD00044553 sodium,oxamate Acetic acid, 2-amino-2-oxo-, sodium salt (1:1) Sodium amino(oxo)acetate Oxalic acid monoamide sodium salt Acetic acid, aminooxo-, monosodium salt EINECS 209-290-5 OXAMIC ACID SODIUM SALT |
| Description | Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1]. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2]. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2]. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2]. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2]. Cell Proliferation Assay[2] Cell Line: CNE-1 and CNE-2 cells Concentration: 10 μM Incubation Time: 24-72 hours Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively. Apoptosis Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 48 hours Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner. Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3. Cell Cycle Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 24 hours Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase. |
| In Vivo | Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2]. Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2] Dosage: 750 mg/kg Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone. |
| Boiling Point | 306.3ºC at 760 mmHg |
|---|---|
| Melting Point | 300 °C |
| Molecular Formula | C2H2NNaO3 |
| Molecular Weight | 111.032 |
| Flash Point | 139ºC |
| Exact Mass | 110.993240 |
| PSA | 83.22000 |
| Storage condition | Store at RT. |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F: Flammable; |
| Risk Phrases | R22;R24/25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2924199090 |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |