270249-38-2
270249-38-2 structure
- Name: 2'-Methoxykurarinone
- Chemical Name: 2'-O-Methylkurarinone
- CAS Number: 270249-38-2
- Molecular Formula: C27H32O6
- Molecular Weight: 452.539
- Catalog: Natural product Flavonoids
- Create Date: 2016-11-28 16:22:18
- Modify Date: 2025-08-26 17:35:54
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(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells[1][2].
| Name | 2'-O-Methylkurarinone |
|---|---|
| Synonyms |
4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxy-2-methoxyphenyl)-5-methoxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
(2S)-7-Hydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-5-methoxy-2,3-dihydro-4H-chromen-4-one Kurarinone, 2'-O-methyl- 2'-Methoxykurarinone |
| Description | (2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.171±0.06 g/cm3 (20 ºC 760 Torr) |
|---|---|
| Boiling Point | 643.6±55.0 °C at 760 mmHg |
| Melting Point | 112-115 ºC |
| Molecular Formula | C27H32O6 |
| Molecular Weight | 452.539 |
| Flash Point | 213.2±25.0 °C |
| Exact Mass | 452.219879 |
| PSA | 85.22000 |
| LogP | 7.05 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.575 |
| Water Solubility | Insuluble (2.6E-4 g/L) (25 ºC) |
| Hazard Codes | Xi |
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