959-23-9

959-23-9 structure

Name: 2-Propen-1-one,1-(4-methoxyphenyl)-3-phenyl
Chemical Name: 4'-methoxychalcone
CAS Number: 959-23-9
Molecular Formula: C₁₆H₁₄O₂
Molecular Weight: 238.28100
Catalog: Biochemical Plant extracts
Create Date: 2018-09-13 18:35:27
Modify Date: 2026-07-30 21:30:49
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

Name	4'-methoxychalcone
Synonyms	Einecs -5 Ccris 1-(4-Methoxyphenyl)-3-phenyl-2-propen-1-one EINECS 213-495-5 METHOXYCHALCONE, 4' 1-(4'-methoxyphenyl)-3-phenylpropenone PP,poly ADP ribose polymerase,inhibit,4'-Methoxychalcone,4' Methoxychalcone,Inhibitor,4'Methoxychalcone RECHEM AM UC 0609 Benzylidene(4-methoxyacetophenone) JR-6849, 4'-Methoxychalcone 1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE 4-Methoxyphenylstyryl ketone MFCD00008407 (E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE β-Phenyl-4'-methoxyacrylophenone Nsc alpha-styryl p-anisyl ketone 4''-Methoxychalcone, 10 mM in DMSO benzylidene-4'-methoxyacetophenone 4''-Methoxychalcone 2-Propen-1-one, 1-(4-methoxyphenyl)-3-phenyl 2-BENZYLIDENE-4'-METHOXYACETOPHENONE Styryl(4-methoxyphenyl) ketone Ai3-25493 4'-METHOXYCHALCONE METHOXYCHALCONE,4'

Description	4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PPARγ[1]
In Vitro	4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1]. 4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1]. 4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1]. RT-PCR[1] Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. Western Blot Analysis[1] Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 8 days Result: Increased PPARγ expression in adipocyte.
References	[1]. Han Y, et al. Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARγ activation and reverse effect on TNF-α in 3T3-L1 cells. Food Chem Toxicol. 2017 Aug;106(Pt A):17-24.

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%