DC Chemicals Limited
China
Product Name: Sterculic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

738-87-4

738-87-4 structure

Name: 8-(2-Octyl-1-cyclopropen-1-yl)octanoic acid
Chemical Name: sterculic acid
CAS Number: 738-87-4
Molecular Formula: C₁₉H₃₄O₂
Molecular Weight: 294.472
Catalog: Signaling Pathways Metabolic Enzyme/Protease Stearoyl-CoA Desaturase (SCD)
Create Date: 2018-07-22 08:44:38
Modify Date: 2025-08-19 22:55:03
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].

Name	sterculic acid
Synonyms	1-Cyclopropene-1-octanoic acid, 2-octyl- Sterculia-Saeure Sterculinic acid Poly-saeure: <C19H34O2>x 9,10-methylene-9-octadecenoic acid 8-(2-octylcyclopropen-1-yl)octanoic acid 8-(2-Octyl-1-cyclopropen-1-yl)octanoic acid Sterculinsaeure Sterculic-saeure

Description	Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD) Research Areas >> Inflammation/Immunology
Target	delta-9 desaturase:0.9 μM (IC50)
In Vitro	Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities[2]. Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2]. Sterculic acid is also able to mediate anti-inflammatory and protective effects[2]. Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].
In Vivo	Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1) in vivo[3].
References	[1]. Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. [2]. Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9(1):140. [3]. Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23(3):305-311.

Density	0.9±0.1 g/cm3
Boiling Point	418.7±24.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₄O₂
Molecular Weight	294.472
Flash Point	315.4±18.0 °C
Exact Mass	294.255890
PSA	37.30000
LogP	7.72
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.487

Hazard Codes	Xi

51526-03-5

738-87-4

Literature: Tetrahedron Letters, , vol. 33, # 11 p. 1521 - 1522

108176-04-1

738-87-4

Literature: Tetrahedron Letters, , vol. 33, # 11 p. 1521 - 1522

143-33-9

152389-88-3

738-87-4

Literature: Tetrahedron Letters, , vol. 33, # 11 p. 1521 - 1522

Precursor 3
51526-03-5 143-33-9 152389-88-3
DownStream 1
3220-60-8

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